Overview

Multi-pH Tris-HCl 1 M Solution Series - The Multi-pH Tris-HCl Series turns GMExpression's existing Tris-HCl pH 8.0 product into a complete routine-lab pH family.

The series is commercially attractive because each pH point uses the same chemistry, equipment, filtration, packaging, and QC framework; only the Tris base/Tris-HCl ratio and final pH verification change.

Use and Applications

  • SDS-PAGE stacking and resolving gel buffer preparation
  • General molecular-biology and protein-buffer formulation
  • Western blot transfer and wash-buffer preparation
  • Cell-culture and physiological assay buffer preparation where Tris is specified

Specifications

ItemSpecification
Individual SKUs1 M Tris-HCl pH 6.8, 7.0, 7.4, 7.5, 8.5, 8.8
Existing companionTris-HCl 1 M pH 8.0 already in GMExpression line
BundleTris-HCl Multi-pH Set, seven pH points including pH 8.0
Bottle500 mL sterile bottle per SKU

Composition 

ComponentAmount / concentrationFunction
Tris baseCAS 77-86-1Base form
Tris-HClCAS 1185-53-1Acid form
HCl / NaOHminor trim onlyFinal pH adjustment
Ultrapure waterq.s. to final volumeSolvent
pH points6.8, 7.0, 7.4, 7.5, 8.0, 8.5, 8.8Routine laboratory coverage

Instruction

1Select the pH point matching the protocol rather than titrating a general stock in-house.
2Dilute the 1 M stock to the required working Tris concentration.
3Check pH at the protocol temperature where temperature sensitivity is important.
4Use pH 6.8 and pH 8.8 SDS-PAGE-labelled variants where gel-casting documentation is desired.

Note

  • Tris has a strong temperature coefficient. A pH measured at 25 deg C will shift at 4 deg C or 37 deg C.

Cautions

Caution. Tris can interfere with amine-reactive crosslinking, Bradford/BCA assays, and some enzyme systems.
Caution. Do not substitute Tris for Good's buffers in metal-sensitive workflows without validation.

Storage and Expiry · Safety

  • Store at room temperature or 2-8 deg C.
  • Unopened shelf life: 24 months from manufacture after QC validation.
  • Transport. Ships at ambient temperature; no cold chain required. Protect from freezing and from temperatures above 40 deg C.
  • Handling and PPE. Wear a laboratory coat, nitrile gloves, and safety glasses for routine handling. Tris is a mild irritant; avoid eye contact. Consult the Safety Data Sheet before use.

References

  1. GMExpression Buffer & pH Indicator Navigator V1.0.

Frequently Asked Questions

Q1. Why list pH 6.8 and pH 8.8 separately from SDS-PAGE buffers?
The chemistry overlaps, but SDS-PAGE-labelled SKUs include application-specific labelling and protocol notes.
Q2. Can custom pH points be made?
Yes. Custom Tris-HCl pH points within the useful Tris range are straightforward.